Título

VISUAL FIELD USING AUTOMATED OR KINETIC PERIMETRY IN CHIASMAL COMPRESSION. CORRELATION WITH RETINAL NERVE FIBER LAYER

Objetivo

To compare visual field (VF) in patients with chiasmal compression with 24-2 standard automated perimetry (SAP) and semiautomated kinetic perimetry (SKP) and assess the relationship between peripapillary retinal nerve fiber layer (pRNFL) and VF loss on SAP and SKP.

Método

Thirty 30 eyes with temporal VF loss from chiasmal compression (CC) and 30 healthy eyes (CT) underwent OCT scanning, Humphrey 24-2 SAP and Octopus 900 SKP with V/4e, I/4e, I/3e and I/2e targets. pRNFL thickness measurements were evaluated globally and in 4-disc quadrants. VF data were evaluated globally and in 4 VF sectors projected to the corresponding disc sectors. Groups were compared using Generalized Estimation Equations. We assessed the relationship between functional and structural parameters, using VF parameters as independent variables and pRNFL thickness as the dependent variables. We evaluated the effect of one single VF predictor using single linear regression (SLR) and using 5 VF predictors using multiple linear regression (MLR) analysis. Significance was set at p ≤ 5%.

Resultado

All pRNFL thickness parameters were significantly reduced in CC compared to CT. SAP and VF area on SKP differed significantly between CC and CT except for the data from central VF area with V4e and I4e. Linear regression showed significant correlation coefficients when using all SAP parameters (range 0.58 to 0.83) and all (range 0.33 to 0.76) but the central VF x temporal disc sector with V/4e and I/4e targets. Intraclass correlation coefficients were greater (range 0.60-0.86) and mean experimental error smaller (range 11.0%-20.8%) in the MLR model using SAP and 4 SKP isopters than in the SLR using SAP alone (range 0.55-0.86, 12.4%-23.6%, respectively).

Conclusão

Adding data from both SAP and the peripheral VF on SKP (isopters V/4e, I4e, I/3e and I/2e) leads to improved correlation and better predicts pRNFL in patients with chiasmal compression and seems important in structure-function relationship studies in visual pathway diseases