Título

RETINAL EVALUATION IN EYES WITH PREVIOUS OPTIC NEURITIS AND AQP4+NMOSD, MOGAD OR DOUBLE-SERONEGATIVE NMOSD

Objetivo

To compare retinal layers thickness using SD-OCT in patients with previous optic neuritis (ON) and neuromyelitis optica spectrum disorder (NMOSD), that have positive anti-aquaporine 4 (AQP4) or anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD), or that are negative for both IgG antibodies.

Método

107 eyes were evaluated and divided in 4 groups: ON-MOGAD, n=32; ON-AQP4, n=32; ON double-IgG seronegative (ON-DSN, n=11); and controls (CTL,n=32). Patients were submitted to complete ophthalmic evaluation, including 24-2 standart automated perimetry (SAP) and OCT (Heidelberg Spectralis™) testing, with acquisition of peripapillary retinal nerve fiber layer(pRNFL), macula full-thickness(mFT) and segmented retinal layers: macular-RNFL(mRNFL), Ganglion Cells(GCL), Inner Plexiform(IPL), Inner Nuclear(INL), Outer Plexiform(OPL), Outer Nuclear(ONL) and Photoreceptors(PhL). The mean thickness was obtained for each layer(Table 1) and data were compared using GEE models. Values of p<0.001 were considered statistically significant.

Resultado

The difference we previously observed that the OPL was thinner in the ON-AQP4 eyes than in the ON-MOGAD was not confirmed with strong statistical significance(p=0.04). With balanced groups, all retinal layers were similar between these two groups.Yet mFT and the inner retina until the IPL were all thinner than controls for all three ON groups. The pRNFL was thinner than controls only in the ON-AQP4 and in the ON-MOGAD eyes. There was also no relevant difference between ON-DSN and the two other groups.(Table 2)
The visual field mean sensitivity(VFMS)of each group was also analyzed and the ON-AQP4 patients showed worse visual function compared with the other two affected groups(Table 3). All three groups had VFMS reduced versus controls

Conclusão

NMOSD compromised more visual function than MOGAD, yet inner macular measures were reduced in all ON eyes similarly, with no statistically significant difference.